The SAVI library is a collection of over a billion synthetically accessible compounds developed at the NIH as an open alternative to commercial chemical spaces. However, handling this vast collection explicitly is computationally demanding for drug discovery applications. To address this, we created...

The ACS Journal Medicinal Chemistry Letters celebrates its 15th anniversary with a special collection of most cited papers. Among them, one of our most visible papers on PoseView, our 2D imaging system for protein-ligand complexes. PoseView is widely used to support scientist in early-phase drug...